When should you think a piece of research can’t be replicated?

Björn Brembs tweeted in this nature article on six red flags for problematic work. The article regards the irreproducibility of a large number of results in cancer research, and is very much directly aimed at their specific methodologies at least for some of the six flags. (I don’t even know what a western blot looks like. I keep imagining cacti and canyons).

Might this recentarticle from Neurobonkers (covering work from Greg Francis) suggest similar key points to look for?

And, just for that, I give you my remote associate: Six Flags Magic Mountain (out west)